LS I生一323A F5F6
細胞核膜是將細胞核中的遺傳物質與細胞質分開的重要構造。失去了此分隔作用會造成基因體的不穩定,也與許多疾病(例如 癌症及早衰症)息息相關。在這個課程中,將會從科學期刊的閱讀與討論當中學習到細胞在不同狀態下是如何維持細胞核膜的 完整性。 The nuclear envelope separates the genome from the rest of the cell, which is critical to the function and stability of the genome. The loss of nuclear envelope integrity is associated with various diseases including cancers and progeria, etc. In this course, students will learn about how cells establish and maintain the integrity of the nuclear envelope under different conditions via reading, presenting, and discussing journal articles.
Course keywords: 細胞核膜,基因體穩定性,核膜組合,核膜破裂, 膜重組 nuclear envelope, genome stability, nuclear envelope assembly, nuclear envelope rupture, membrane remodeling 一、課程說明 本課程的目標為全面性的了解細胞核膜的組合和重組。學生需要閱讀相關文獻並上台報告,並且參與討 論。 需與授課教師討論後加簽選課。 The objective of this course will be to comprehensively understand the assembly and remodeling of nuclear envelope in the cell. This will be achieved by reading and presenting classic and current literatures on nuclear envelope integrity, and discussion in an interactive environment. Permission from the instructor is required. 二、指定用書 無 N/A 三、參考書籍 分子細胞生物學教科書相關章節及期刊文章 Molecular Cell Biology textbook chapters and current literature 四、教學方式 學生們將閱讀期刊文章並輪流上台報告,並參與由指導老師帶領的討論。 The students will read assigned literatures and take turns presenting the paper. The students are also expected to participate in discussions. 五、教學進度 本課程將會包含以下的主題: R26; 細胞核膜的研究方法 R26; 當下對核模組合的了解 R26; 細胞核膜不正常表徵與基因體穩定性 Major topics that will be included in this class: R26; Methodologies for studying nuclear envelope remodeling. R26; Current understanding of nuclear envelope assembly and knowledge gaps. R26; Nuclear atypia and genome stability. 六、成績考核 50% 出席,25% 上台報告,25% 討論。 50% attendance, 25% presentation, 25% discussion.
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需與授課教師討論後加簽選課Requiring application in order to enroll in the course.
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